letter of motivation to get biology students
Biology was your first subject matter that actually received a 10 year old me engaged when I first learned the science at the rear of heart attack. Seeing so many people experience such problems given my family’s medical history led to me personally deciding to find a cure. Yet , small and insignificant this show may seem but it was enough to stir up in my mind the curiosity in the intricacies of human body. Very little did I understand that one school lecture might throw me into this enthralling and mystifying world of biological sciences. All through college with every school, I was simply persuaded to delve deep into the subject matter.
This kind of insatiable desire for the niche propelled me personally to go to get a Bachelors in Science with the biological topics. The choice of study course wasn’t hard to make. Francis Crick was right when he said that it had been the molecule that has the glamour, not the scientist. The study of molecules sustaining lifestyle had to be the main element to get to the core of the subject and unravel biology in a different way altogether.
The undergraduate system was a new avenue where I got subjected to various areas of research. It was fun to finally be able to get essentially of the simple facts that individuals were presented with at the institution. The two segments that gained my engrossment were cell biology and molecular biology.
Through long, the double helical structure kept together simply by specific pairing between the angles on two strands started to be one of the well-known images of science. However , it was simply later inside our molecular biology lectures that I realized that this molecule is a lot more sophisticated than it looks. Additionally, learning which the modest picture of a typical cell with organelles is extravagantly dynamic acquired me overcome.
Therefore, complexity of mechanisms linked to cell biology and molecular biology shows a particularly convincing drama and one only gets filled with plenty of remaining mysteries.
The contribution of molecular biology and cell biology to the clinical revolution has been immense. Coming from production of vast amount of rare drugs and vaccines, tracing advancement, creating immediate test for a host of illness, to identification of criminals. Jointly these two fields have practically encompassed the whole spectrum of science by physics and chemistry to biology and medicine. I feel, this field would allow me personally to study lifestyle on every level from individual molecules to the interrelated webs of earth’s organisms. Above all, I believe this can be one of the most tough and possibly rewarding areas.
Subsequent comes the daunting process to get at a particular area from these two huge fields. The discipline which i felt could perfectly straddle these two areas is cancers and epigenetics.
Siddharta Mukherjee in the book ‘The Emperor of All Maladies’, defined cancer because an much resourceful attacker. This declaration definitely struck a chord. Cancer can be described as global foe no doubt but to describe this as formative is what was unique and made me realize the research potential of this worldwide occurring trend.
Tumor is an amalgam of many diseases showing a common feature of unnatural growth. Analysts all over the world as a result have come plan different approaches to tackle it.
One particular approach that seemed quintessential to my personal interest is definitely epigenetics. Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional legislation locally and globally by means of modifications of the DNA through modification or perhaps rearrangement of nucleosomes. Global changes in the epigenetic landscape really are a hallmark of cancer. GENETICS methylation normally takes place in the 5 location of the cytosine ring inside CpG dinucleotides, and its consequence is the silencing of genes and noncoding genomic areas.
Histone modification such as acetylation and methylation are essential in transcriptional regulation. Normally, about 70-80% of all CG dinucleotides inside the genome happen to be methylated and the remainder CG dinucleotides occur in clusters known as CpG islands near the 5′ end of genes and they are protected from methylation. So , Cpg area hypermethylation and genome vast hypomethylation are typical epigenetic features of cancer cells. Too much methylation in CpG island can cause activation of nearby oncogens and too little methylation across the genome can lead to silencing of tumor suppressor genes. In addition, cancer cellular material also have a histone cancer signature caused by deacetylation of several lysine resuides.
Hence if offered an opportunity I might want to work in this kind of field to study and identify epigenetic markers on cancers cells. This is highly important seeing that identification of specific epigenetic profiles of types and subtypes of cancer can be utilised as a classification tool and identification with the stage of development of tumor in sufferers.