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After looking over the fabric regarding Centagenetix, I have a suggestion as to whether or not MPM should invest in Centagenetix. I know that we have put in a great deal of as well as resources about this project already, and that Harvard Medical Institution is anticipating that this deal will go forward. I as well realize that support out of the deal now could reflect poorly upon MPM and after you, yet my suggestion is that MPM invest in Centagenetix at this point.

The key reason is that in the event that Centagenetix is in fact able to create a product to increase human extended life, there are some major questions and concerns about first receiving this product to advertise, as well as what conditions this product might carry for considerable efficacy of course, if the market will probably be willing to accept them. I will discuss various other considerations shortly but I believe that is by itself a potential deal-breaker. Let us 1st consider the modern England C Study (NECS). While it is actually a worthwhile and interesting examine, with good correlations between family members and a sample pool large enough to supply preliminary studies, it keeps having some weak points.

Both major kinds being just how geographically centric it is and the size of this. Scientists whom study maturing have long argued that environment and lifestyle enjoy the largest part in extended life, but Centagenetix is aiming to see if that may be incorrect: if there is in fact a heritable gene (or genes) for longevity. It would seem that in order to provide a powerful argument the fact that study reaches beyond environment, there should be even more samples by areas beyond the ten towns around Boston which the NECS applied. It could become a problem that the majority of the centenarians used experienced no history of smoking or perhaps obesity and were generally small in stature. Approved that using these samples, they discovered a linkage on chromosome 4, yet this does not seem to match the homologous specific zones for durability in the previously studied style organisms.

There are possible correlations on additional chromosomes that track with those unit organisms, however the patent that they filed is for the 15 million foundation pair place on chromosome 4. I actually am as well concerned that the first make an effort to scale the research to a bigger population resulted in a popular decrease of the linkage’s strength. Scaling it up further refurbished the record strength in the linkage, but the overall power and valuation of the IP remains involved. We must also consider the chance that this 10M bp region will include genes that other organizations are already studying and that the patent is certainly not strong enough to outlive a challenge. It is possible that these longevity genes will be related to insulin receptors or free radical management: two areas that several teams or businesses are already learning. How strong will the IP remain once there is competition for these hypothetical genes? In the event that is the case, the company’s major resource will probably be its SNP database of centenarians, that may cost in least another $10 mil to get to a practical state, and even more money to expand and look after it. I use not noticed any market analysis regarding how much companies will pay intended for access to this kind of a database. While Millennium has a to some extent similar version, they are a lot more pro-active in what they offer their very own clients, that is certainly what probably drives their very own profits. The database will probably be valuable, nevertheless just how useful is an important query. We need to know what the likelihood is that building such a SNP database can turn a profit, whom specifically will be interested in purchasing its work with, and how very much they would shell out. In addition , would Centagenetix acquire any royalties or repayments for items based off findings as a result SNP data source? These are features of consideration, especially if the probability exists the fact that SNP databases will have to support the company for just about any protracted amount of time. There remains a conflict-of-interest issue with Jeff Perls and Harvard. In the event that he can always be enticed far from Harvard, the study that the organization is based on is going to potentially no longer be available. Perls will be a essential founding member of Centagenetix, and is also expected end up being motivated and incentivized to work hard. With no stake in the company, it remains unclear if that may happen. We all also need to consider that if Perls does leave Harvard, will BIDMC still enable Centagenetix the NECS, or should all of us re-consider the proposal via Whitehead to buy them out? The value of the IP centers strongly throughout the NECS and Dr . Perls’ work.

Presently there needs to be a far clearer perception as to if perhaps or how these issues will be resolved, if not MPM may own a key stake within a company that may require a much larger investment to restore the IP we have thought they already have. Finally, I want to return to my key point: Apart from a SNP database, precisely what is at the end with the Centagenetix pipeline? Let us imagine they do look for a gene or several genes that straight relate to extended life and are not really in conflict with another group or firm, that they can find the function of these genes, and eventually produce a product built on that discovery. Presumably, the function of this product would be to maximize longevity in humans. How would they run clinical trials for this, and how long could they take? If the measure of success is how long someone lives, might not the trials consider far much longer than is usually feasible for us to provide financing? Assume that they get past pre-clinical trials; will the FDA even allow such a product to become tested? I believe that we have to know more about how precisely the FDA would approach such an item, as it seems like the regulatory hurdles for this will not be what most pharmaceutic companies are comfortable with. They are not trying to take care of or impact a disease point out, but rather to enhance longevity. Approved that Ponce de León spent most of his lifestyle searching Fl for the Fountain of Youth, and this a product like this will charm to the average person, there is probably some critical regulatory and clinical trial hurdles to get it presently there. We should also consider how the medical community and community will respond to such a product. It seems probably that, offered how lots of the subjects from your NECS were living relatively healthy and balanced lives, the item will have a few stipulations about health to get maximum efficacy. If the public is required to not smoke, or perhaps be obese before this system will work for them then that may significantly have an effect on adoption. Additionally , how would the medical community interact to something with claims of increasing longevity?

I believe it would be very skeptical and cynical. You will see difficulty in both equally convincing doctors to recommend it, along with getting payers to compensate for it. This will presumably be a item that patients will take for years to come, meaning there will likely be a have difficulties for equally adoption and compliance. The only real gauge of such a product will probably be how long an individual lives, but it will surely be difficult to demonstrate evidence that any increase in extended life is a immediate result of Centagenetix’s product. Significant market research must be done that considers the varying scenarios for adoption and changes in lifestyle, to see if industry size is as big as one would expect it to be. In conclusion, I acknowledge that other products may come out of Centagenetix which have been related to actual disease states or physical processes. It will be possible that they will develop an impressive and profitable medicine that is related to the longevity of the sufferers of the NECS and past. Heck, they could even find out the cure to get cancer. Even so, there are too many unknowns and uncertainties from this proposal. The effectiveness of the IP is in issue. The availability of the NECS and even Dr . Perl is unsure. What a finish product seems like and what kind of market is out there for it. Simply how much more money it may need if they must build a SNP database to keep in business, or perhaps if they need to do one other NECS-like study of their own. The risks and questions are significant, and the problem about genuine market dimensions are significant. I do not feel that MPM ought to invest in Centagenetix at this point.

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